Clinton Health Access Initiative

Scientific Director, Process Chemistry Team

Country
United States
Type
Full Time
Program (Division)
Global Health Sciences - Process Chemistry Team

Overview

The Clinton Health Access Initiative, Inc. (CHAI) is a global health organization committed to saving lives and reducing the burden of disease in low-and middle-income countries, while strengthening the capabilities of governments and the private sector in those countries to create and sustain high-quality health systems that can succeed without our assistance. For more information, please visit: http://www.clintonhealthaccess.org

 

Overview of Team:

 

The Process Chemistry Team (PCT) was founded early in CHAI’s mission to add technical credibility to price negotiations with generic partners and to focus negotiation efforts on rational antiretroviral (ARV) drug targets. This expertise has allowed CHAI to direct purchasing programs toward suppliers who can deliver quality drugs at the best prices. After learning how lower manufacturing costs could improve their profitability and market share, drug manufacturers may be encouraged to implement these technical innovations. To this end, PCT began networking with collaborators to develop research contracts with various groups and establish a chemistry laboratory to conduct background analyses of manufacturing processes, and perform and coordinate process chemistry research to optimize active pharmaceutical ingredients (API) manufacturing in the areas of HIV, malaria, direct-acting antivirals for hepatitis C, tuberculosis, and several essential medicines. Recently, PCT has expanded its scope to work on new drug products for low/middle income countries (LMICs) in early development.

 

Overview of Role:

 

This Scientific Director will work closely with the Director of Process Chemistry, other Process Chemistry team members, and CHAI partners to support the development of long-acting formulations of drugs.  The work will include optimizing and scaling up APIs in the CHAI laboratory and supporting good manufacturing processes (GMP) of clinical trial material. This individual will have overall responsibility for designing and implementing experiments in the CHAI lab and ensuring high quality data is collected, analyzed, communicated and stored appropriately.

 

This role is based in Newark, Delaware, United States.

Responsibilities

  • Develop scalable synthetic processes to reduce costs of drugs of interest, from ideation of the experiments that need to be run to execution in CHAI’s laboratory.
  • Develop and run analytical methods to test outcome of experiments.
  • Document the outcome of lab work in technical papers and reports. Communication and transfer of results to manufacturers and to partners. 
  • Maintain instruments and equipment. Troubleshoot issues when they arise. 
  • Assessment of potential manufacturers and contract research organizations involved in CHAI's research and development efforts
  • Partner with academic groups and NGOs to advance global health through the development of better, safer, and less expensive medicines.
  • Contribute to CHAI and CHAI's Global Health Sciences department, including providing advice to other teams and CHAI collaborations, supporting the department’s fund raising and grant writing activities, and support for various product initiatives.

Qualifications

  • PhD in synthetic organic chemistry is preferred
  • More than 10 years of experience in process chemistry in a pharmaceutical industrial setting
  • Ability and desire to work in the laboratory is essential
  • Recent experience with GMPs at lab scale and a deep understanding of the changing regulatory requirements for APIs and the finished products throughout development are essential
  • Evidence of a high level of accomplishments as demonstrated by publications, patents, successful drug launches and career progression
  • Ability to use and maintain analytical instruments typical of an organic lab
  • Able to communicate, both oral and written, with diverse teams
  • Familiarity with Microsoft suite of programs
  • Entrepreneurial mindset, including ability to work independently, self-motivate, and propose and implement new initiatives
  • Ability to be effective in high-pressure situations, handle multiple tasks simultaneously, and set priorities
  • Detail-oriented with strong organization skills

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