The Clinton Health Access Initiative, Inc. (CHAI) is a global health organization committed to saving lives and reducing the burden of disease in low-and middle-income countries, while strengthening the capabilities of governments and the private sector in those countries to create and sustain high-quality health systems that can succeed without our assistance. For more information, please visit: http://www.clintonhealthaccess.org
Overview of Team:
CHAI's Process Chemistry Team (PCT) provides a rare, transformative opportunity to help provide lifesaving drugs to millions of people in low-middle-income countries. The PCT was founded early in CHAI’s mission to add technical credibility to price negotiations with generic partners and to focus negotiation efforts on rational antiretroviral (ARV) drug targets. Since its inception, PCT has played a critical role in transforming the process chemistry of drugs by finding more cost-effective ways to manufacture lifesaving drugs; and in doing so, demonstrating that cost of goods can be dramatically reduced.
The group works on products that are in under development as well as products that have already been commercialized. Our team is able to achieve this by conducting detailed literature and patent analyses of relevant but more advanced manufacturing processes, using this knowledge to perform process chemistry research to optimize active pharmaceutical ingredients (API) manufacturing in CHAI’s laboratory as well as networking with industrial and academic collaborators to advance our work.
Through our work, the team has opened the opportunity for essential medicines to be accessible in low-middle-income countries and save millions of lives.
Overview of Role:
The Principal Scientist will work with the PCT Director and CHAI disease and technical leads to agree on a portfolio of drug products that will have substantial markets and whose chemistries are excellent candidates for optimization. For each of these drug candidates, the Principal Scientist will then design and implement process chemistry optimization strategies in the lab that will be simpler, safety, greener, less expensive, and based on readily available and high-quality raw materials. Critical to the success of our work is to ensure these approaches are highly scalable and these capabilities are transferred to quality manufacturers.
The Principal Scientist will also collaborate with CHAI partners (both in academic and non-academic settings) and engage with innovator and generic manufacturers in India, China and Africa. This position also supports good manufacturing practices (GMP) of clinical trial material and the development of long-acting formulations of drugs. Finally, this role provides a cornerstone of CHAI's work to ensure that better, high-quality, lower-cost products are available to more people who need care.
This role is based in Newark, Delaware, United States.